The series is executive produced by showrunner Steve Lightfoot (Hannibal), Jim Chory (Marvel’s Daredevil, Marvel's Jessica Jones, Marvel's Luke Cage) and Jeph Loeb (Marvel’s Daredevil, Marvel's Jessica Jones, Marvel's Luke Cage) who also serves as Marvel’s Head of Television. Marvel’s The Punisher is produced by Marvel Television in association with ABC Studios for Netflix.

The cast also features Ebon Moss-Bachrach (Girls, The Lake House), Deborah Ann Woll (Marvel’s Daredevil, True Blood), Ben Barnes (Westworld, The Chronicles of Narnia), Amber Rose Revah (Emerald City, Indian Summers), Michael Nathanson (The Knick, Wolf of Wall Street), Jaime Ray Newman (Bates Motel), Jason R Moore (A Lonely Place for Dying), Daniel Webber (11.22.63) and Paul Schulze (Nurse Jackie).